Functional differences in hepatitis C virus nonstructural (NS) 3/4A- and 5A-specific T cell responses
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چکیده
منابع مشابه
Functional differences in hepatitis C virus nonstructural (NS) 3/4A- and 5A-specific T cell responses
The hepatitis C virus nonstructural (NS) 3/4A and NS5A proteins are major targets for the new direct-acting antiviral compounds. Both viral proteins have been suggested as modulators of the response to the host cell. We have shown that NS3/4A- and NS5A-specific T cell receptors confer different effector functions, and that killing of NS3/4A-expressing hepatocytes is highly dependent on IFN-γ. W...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2016
ISSN: 2045-2322
DOI: 10.1038/srep24991